A systematic review by US authors has concluded that Chinese herbal medicine may increase the effectiveness of infertility treatment with the drug clomiphene citrate (CC). Fourteen randomised studies representing 1316 patients met their inclusion criteria. Four studies (n=315) reported a 14% higher likelihood of biphasic basal body temperatures. Six studies (n=604) reported a non-significant 18% increase in ovulation rates. Two studies (n=138) reported subjects 78% more likely to have endometrial lining greater than 6mm. Thirteen studies (n=1202) reported a 50% increase in pregnancy rates. The authors noted the poor methodological quality and small sample size of published trials and called for more rigorously controlled studies. (Chinese herbal medicine and clomiphene citrate for anovulation: a meta-analysis of randomized controlled trials. J Altern Complement Med. 2011 May;17(5):397-405).

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