Acupuncture has been shown to be effective in reducing fatigue and improving the quality of life for individuals with relapsing-remitting multiple sclerosis (RRMS). A study conducted by Iranian researchers compared the impact of acupuncture plus amantadine to amantadine alone in managing fatigue among 60 patients with RRMS in the remission stage of the disease.  Participants were randomly divided into two equal groups.  The acupuncture group received acupuncture treatment two to three times per week for a total of 10 sessions over four weeks.  Both the acupuncture group and the control group received amantadine (100 mg daily) in addition to routine treatment with immunomodulators.  Both groups experienced a reduction in the severity of fatigue compared to their baseline levels.  However, after four weeks of treatment, the acupuncture group showed a more significant reduction in fatigue compared to the control group (mean difference (MD) = -1/14).  Additionally, the acupuncture group demonstrated a significant improvement in their quality of life, including mental and physical status, when compared to the control group (MD = 9.09). (Effectiveness of acupuncture for fatigue in patients with relapsing-remitting multiple sclerosis: a randomized controlled trial. Acupunct Med. 2023 Aug;41(4):199-205).