Acupuncture is cost-effective compared with counselling or usual care alone for patients with depression, according to analysis of the results of a major UK trial. Cost-effectiveness analyses were based on the results of the Acupuncture, Counselling or Usual care for Depression (ACUDep) trial. Statistical analyses demonstrated a difference in mean quality adjusted life years (QALYs) and suggested differences in mean costs which were mainly due to the cost of delivering the interventions. Acupuncture and counselling were found to have higher mean QALYs and higher costs than usual care. Acupuncture was shown to have an incremental cost-effectiveness ratio (ICER) of £4,560 per additional QALY and was shown to be cost-effective with a probability of 0.62, at a cost-effectiveness threshold of £20,000 per QALY. Compared with acupuncture counselling is more effective and more costly with an ICER of £71,757 and a probability of being cost-effective of 0.36. (Cost-Effectiveness Analysis of Acupuncture, Counselling and Usual Care in Treating Patients with Depression: The Results of the ACUDep Trial. PLoS One. 2014 Nov 26;9(11):e113726).